EMBO J., 9, 3343–3351.īrown LA, Rodaway AR, Schilling TF, Jowett T, Ingham PW, Patient RK and Sharrocks AD. USA, 90, 6028–6031.īrown L, Cheng JT, Chen Q, Siciliano MJ, Crist W, Buchanan G and Baer R. Genes Dev., 16, 2958–2970.īrecher G, Bookstein N, Redfearn W, Necas E, Pallavicini MG and Cronkite EP. Blood, 98, 643–651.īouchard M, Souabni A, Mandler M, Neubuser A and Busslinger M. USA, 86, 2031–2035.īennett CM, Kanki JP, Rhodes J, Liu TX, Paw BH, Kieran MW, Langenau DM, Delahaye-Brown A, Zon LI, Fleming MD and Look AT. Development, 129, 3311–3323.īegley CG, Aplan PD, Davey MP, Nakahara K, Tchorz K, Kurtzberg J, Hershfield MS, Haynes BF, Cohen DI, Waldmann TA and Kirsch IR. Growth Differ., 19, 171–179.Īmacher SL, Draper BW, Summers BR and Kimmel CB. Given that many of the regulatory genes that control embryonic hematopoiesis have been implicated in oncogenic pathways in adults, an understanding of blood cell ontogeny is likely to provide insights into the pathophysiology of human leukemias.Īl-Adhami MA and Kunz YW. Here, we provide a detailed review of the timing, anatomical location, and transcriptional regulation of zebrafish ‘primitive’ and ‘definitive’ hematopoiesis as well as discuss a model of T-cell leukemia and recent advances in blood cell transplantation. As in other vertebrates, all of the teleost blood lineages are believed to originate from a pool of pluripotent, self-renewing hematopoietic stem cells. As a result, most (if not all) of the critical hematopoietic transcription factor genes identified in mammals have orthologues in zebrafish. Despite extensive evolutionary divergence between bony fish (teleosts) and mammals, the molecular pathways governing hematopoiesis have been highly conserved. Progressive advances using zebrafish as a model organism have provided hematologists with an additional genetic system to study blood cell formation and hematological malignancies.
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